When i stroke a gesture on Regedit, TaskManager it does nothing it just skip it(Not even draw!) in safe mode all works. P.S. Windows 10 Pro x64 10586.0
If you are not running the signed version of S+ from the Program Files folder, S+ will not have permissions to interact with elevated programs. Either run S+ as I mentioned above, or run S+ with administrative privileges.
I run Win 10 64bit and have never had an issue with Chrome. Are you running the signed version from Program Files? Not that it really should matter, but curious.